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1 ºñ°ø°³ ¼Õ´Ô ¡¦ 2014-12-17 17:40:12
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2 ºñ°ø°³ ¼Õ´Ô ¡¦ 2014-12-17 17:44:03
The LD50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 30–60 mg (0.5–1.0 mg/kg) can be a lethal dosage for adult humans.[7][48] However the widely used human LD50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal outcomes is 500–1000 mg of ingested nicotine, corresponding to 6.5–13 mg/kg orally.[9] Nevertheless nicotine has a relatively high toxicity in comparison to many other alkaloids such as caffeine, which has an LD50of 127 mg/kg when administered to mice.[49]

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3 ºñ°ø°³ ¼Õ´Ô ¡¦ 2014-12-17 17:44:33
The lethal dose for potassium cyanide is 200–300 mg.[9] Its toxicity when ingested depends on the acidity of the stomach, because it must react with an acid to become hydrogen cyanide, the deadly form of cyanide. Grigori Rasputin may have survived a potassium cyanide poisoning because his stomach acidity was unusually low.

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